Research background: In taxonomy, mice belong to Mammalia, Rodentia, Muridae, and Mus animals. Mice are evolved from the house mouse. It is widely distributed around the world and has been bred for more than 1,000 after long-term artificial breeding selection 
Inbred lines and independent outbred groups. As early as the 17th century, humans used mice for experiments, and now it has become the most used and most thoroughly studied mammalian laboratory animal.
Significance:
1. Safety and toxicity test
Mice are often used for safety tests of food, cosmetics, medicines, chemical products, etc., acute, subacute, and chronic toxicity tests. They can also be used for teratogenic, carcinogenic, and mutagenic tests, and the determination of half-lethal amount.
2. Biological effect determination and drug potency comparison
It is widely used in the identification of serum, vaccine and other biological products, to conduct biological effect experiments and to determine the potency of various drugs.
3. Drug screening
Most screening experiments start with mice, screening various drugs for the prevention and treatment of diseases, and after screening to obtain the curative effect of each drug, then use other animals to further affirm.
4. Microbiology, parasitology research
Mice are sensitive to multiple pathogens. Especially in virology research 
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It is suitable for studying schistosomiasis, malaria, trypanosomiasis, influenza, encephalitis, rabies, poliomyelitis, lymphoid choroid meningitis, mycoplasma, pasteurella, salmonella, etc.
5. Radiology Research
The response of mice to radiation is comparable to that of humans, and can be used to study the radiation dose and radiation effects.
6. Cancer and leukemia research
The incidence of tumors in mice is high, the inbred strains have good tissue compatibility, and tumor transplantation is easier to grow, so it is widely used. Anti-tumor drugs can be screened for spontaneous tumors in mice. It can induce various tumors, make tumor models, and conduct research on tumor etiology and morbidity. Some inbred mice belong to the high-cancer line and some belong to the low-cancer line, which is convenient and beneficial for studying tumorigenesis.
7. Family Planning Research
Mice have a regular estrous cycle, ovulation, pregnancy has obvious indicators, easy to detect, cheap, commonly used for anti-fertility, anti-implantation, anti-early pregnancy, anti-ovulation experiments, very suitable for contraceptive research.
8. Antitussive Research
Mice have a cough reaction, available 
One characteristic is to study antitussive drugs and become a must-have experimental animal.
9. Genetic disease research
There are many strains of mice, and some have spontaneous genetic diseases, such as mouse melanopathy, albinism, familial obesity, and hereditary anemia. They are similar to human diseases and can be used as animal models of human genetic diseases.
10. Immunology research
Various immunodeficiency mice, such as pure New Zealand black mice (NZ has autoimmune hemolytic anemia, AKR / N strain mice have complement C5 defect, CBA / N mice have no B cell immune deficiency, etc. A good experimental animal to study the immune mechanism and immunodeficiency disease.
11. Gerontology research
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