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Freeze-drying (hereinafter referred to as lyophilization) is a method in which a water-containing substance is first frozen into a solid state, and then the moisture therein is sublimated from a solid state to a gaseous state to remove the water and preserve the substance. In the compressed air drying process, the freeze-drying is through the reduction of the compressed air temperature, so that the moisture in the compressed air precipitation. The working principle of the freeze dryer (cold dryer) is the same as that of the refrigerator. After the compressed air passes through the frozen compressed air pipe, the compressed air temperature drops to the required temperature and reaches the drying requirement.
Western medicine freeze-drying has obtained certain development in China. Many large-scale pharmaceutical plants have freeze-drying equipment. In terms of injections, the freeze-drying process is used more often, which improves the quality of medicines and the shelf life, and brings benefits to both doctors and patients. There are not many types of lyophilized drugs, the product price is high, and the drying process is not advanced. In traditional Chinese medicine, ginseng, pilose antler, yam, Cordyceps sinensis and other small amounts of Chinese herbal medicines are lyophilized, and a large number of proprietary Chinese medicines have not yet been lyophilized and have a large gap with foreign countries. In Japan a few years ago, it began to develop “Western Medicine Chinese Medicineâ€, which changed the tanning method of traditional Chinese medicines, solved the traditional Chinese medicine that could not be made into injections or tablets, and also solved the problems of incurable acute diseases of traditional Chinese medicines. And product research has great potential to be tapped. In the field of biotechnology products, freeze-drying technology is mainly used for the production of serum, plasma, vaccines, enzymes, antibiotics, hormones and other drugs; biochemical examination of drugs, immunology and bacteriological examination of drugs; blood, bacteria, arteries, bones , skin, cornea, nerve tissue and various organs for long-term preservation. The status quo of equipment and development of freeze-dried technology applications and equipment are inseparable. So far, the form of freeze-dried equipment is mainly divided into intermittent and continuous two categories, the scale of the equipment from less than a square meter to a few There are ten square meters. Intermittent freeze-drying equipment Intermittent freeze-drying equipment is suitable for multi-variety and small-batch production, especially in the food field for seasonally strong food production. Using stand-alone operation, if one device fails, it will not affect the normal operation of other devices. Intermittent lyophilization equipment facilitates control of the heating temperature and vacuum requirements at different stages of the drying of the material. Equipment manufacturing and maintenance are easy to perform.
However, since the loading, discharging, starting and other operations take a lot of time, the utilization rate of the equipment is low, and the production efficiency is not high. Continuous freeze-drying equipment has begun to explore and use continuous vacuum freeze-drying equipment at home and abroad. The continuous equipment is characterized by being suitable for the production of a single product with a large output and ample raw materials, and is particularly suitable for the production of paste and granular products. The continuous equipment is easy to implement automatic control and simplifies manual operation and management. Its main disadvantage is its high cost. With the end of the GMP certification, domestically produced freeze drying equipment for pharmaceuticals has fully entered the modernization stage, with complete functions, reliable work, and stable performance. Online cleaning or steam sterilization can be achieved. All technical indicators can meet biological products and Drug freeze-dry production needs. In contrast, foreign freeze-dried equipment has more specifications than domestic ones, complete supporting equipment, more energy-efficient structures, and continuous freeze-drying equipment. In order to guarantee the quality and energy saving of freeze-dried products, a combination freeze-drying apparatus in which a freeze-drying apparatus is combined with other drying apparatus is often used, for example, a spray freeze-drying apparatus. In the future, how to improve the efficiency of freeze-drying, shorten the drying time, and save energy will be the goal of the majority of freeze-drying industry workers under the premise of ensuring product quality.
Shanghai Xinzhuang adheres to the principle of quality for survival, technology for development, management for efficiency, and service for credibility. Every equipment, every project and each link is strictly followed. Excellent quality and service win the trust of customers. Because of the professional choice, Shanghai Xinzhuang welcomes you, and our strong technical team supports you!
Shanghai Xinzhuang Instrument Co., Ltd. welcomes your inquiry http://?
Freeze-drying (hereinafter referred to as lyophilization) is a method in which a water-containing substance is first frozen into a solid state, and then the moisture therein is sublimated from a solid state to a gaseous state to remove the water and preserve the substance. In the compressed air drying process, the freeze-drying is through the reduction of the compressed air temperature, so that the moisture in the compressed air precipitation. The working principle of the freeze dryer (cold dryer) is the same as that of the refrigerator. After the compressed air passes through the frozen compressed air pipe, the compressed air temperature drops to the required temperature and reaches the drying requirement.
Western medicine freeze-drying has obtained certain development in China. Many large-scale pharmaceutical plants have freeze-drying equipment. In terms of injections, the freeze-drying process is used more often, which improves the quality of medicines and the shelf life, and brings benefits to both doctors and patients. There are not many types of lyophilized drugs, the product price is high, and the drying process is not advanced. In traditional Chinese medicine, ginseng, pilose antler, yam, Cordyceps sinensis and other small amounts of Chinese herbal medicines are lyophilized, and a large number of proprietary Chinese medicines have not yet been lyophilized and have a large gap with foreign countries. In Japan a few years ago, it began to develop “Western Medicine Chinese Medicineâ€, which changed the tanning method of traditional Chinese medicines, solved the traditional Chinese medicine that could not be made into injections or tablets, and also solved the problems of incurable acute diseases of traditional Chinese medicines. And product research has great potential to be tapped. In the field of biotechnology products, freeze-drying technology is mainly used for the production of serum, plasma, vaccines, enzymes, antibiotics, hormones and other drugs; biochemical examination of drugs, immunology and bacteriological examination of drugs; blood, bacteria, arteries, bones , skin, cornea, nerve tissue and various organs for long-term preservation. The status quo of equipment and development of freeze-dried technology applications and equipment are inseparable. So far, the form of freeze-dried equipment is mainly divided into intermittent and continuous two categories, the scale of the equipment from less than a square meter to a few There are ten square meters. Intermittent freeze-drying equipment Intermittent freeze-drying equipment is suitable for multi-variety and small-batch production, especially in the food field for seasonally strong food production. Using stand-alone operation, if one device fails, it will not affect the normal operation of other devices. Intermittent lyophilization equipment facilitates control of the heating temperature and vacuum requirements at different stages of the drying of the material. Equipment manufacturing and maintenance are easy to perform.
However, since the loading, discharging, starting and other operations take a lot of time, the utilization rate of the equipment is low, and the production efficiency is not high. Continuous freeze-drying equipment has begun to explore and use continuous vacuum freeze-drying equipment at home and abroad. The continuous equipment is characterized by being suitable for the production of a single product with a large output and ample raw materials, and is particularly suitable for the production of paste and granular products. The continuous equipment is easy to implement automatic control and simplifies manual operation and management. Its main disadvantage is its high cost. With the end of the GMP certification, domestically produced freeze drying equipment for pharmaceuticals has fully entered the modernization stage, with complete functions, reliable work, and stable performance. Online cleaning or steam sterilization can be achieved. All technical indicators can meet biological products and Drug freeze-dry production needs. In contrast, foreign freeze-dried equipment has more specifications than domestic ones, complete supporting equipment, more energy-efficient structures, and continuous freeze-drying equipment. In order to guarantee the quality and energy saving of freeze-dried products, a combination freeze-drying apparatus in which a freeze-drying apparatus is combined with other drying apparatus is often used, for example, a spray freeze-drying apparatus. In the future, how to improve the efficiency of freeze-drying, shorten the drying time, and save energy will be the goal of the majority of freeze-drying industry workers under the premise of ensuring product quality.
Shanghai Xinzhuang adheres to the principle of quality for survival, technology for development, management for efficiency, and service for credibility. Every equipment, every project and each link is strictly followed. Excellent quality and service win the trust of customers. Because of the professional choice, Shanghai Xinzhuang welcomes you, and our strong technical team supports you!
Shanghai Xinzhuang Instrument Co., Ltd. welcomes your inquiry http://?