According to the British Daily Mail report, at present, Organovo, California, uses a 3D printer to manufacture a miniature liver organ with a depth of only 0.5 millimeters and a width of 4 millimeters. Protein, salt and drugs are delivered throughout the body.
Scientists at Organovo, California, USA use bioprinters to print "mini liver" layer by layer in the laboratory
Miniature liver organs have many real organ functions, including: production of important proteins and cholesterol
Organovo used a 3D printer to print about 20 layers of living cells layer by layer, thus creating this kind of micro-organ, which accompanied the cells from the blood vessels to the liver organs to deliver nutrients and oxygen. Crucially, the addition of blood cells means that this 3D cellular tissue can survive for more than 5 days.
Miniature liver organs form a great contrast with 2D cultured cells. The latter is based on single-layer or double-layer cells and can only survive for 2 days. It does not have the unique function of Organovo's development of miniature livers. The company will work on developing organs of real size that can be transplanted. At present, this miniature liver can produce albumin, as well as cholesterol and cytochrome P450s, which can metabolize drugs in liver organs and is an enzyme with detoxification effect. .
The true structure and function of the miniature liver organs combined with the hepatocyte layer and hepatic stellate cell layer can have a positive impact on the study of infectious diseases or monitor drug therapy. It can perform blood filtration, metabolism and delivery of drugs, and produce some proteins essential for homeostasis.
Some family genetic diseases are usually closely related to the lack of protein, and the protein is produced by the liver. At present, scientists from the San Diego laboratory in California will print a larger network of blood vessels to nourish the actual size of human organs and tissues.
It is reported that the 3D printer used by Organovo has two print heads, one is responsible for printing scaffolding, and the other prints human cells layer by layer to form an organ structure.
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