The stem cells were taken out from the rabbits, placed on a 3D printed stent, cultured in vitro for 4 weeks, and then inoculated into the subcutaneous culture of nude mice, and finally the desired cartilage tissue can be grown. This is the 3D used by Nanjing Medical University affiliated to Nanjing Medical University. An attempt at printing technology. On this basis, on November 4th, the Institute of Digital Medicine of Nanjing Medical University was unveiled at Nanjing Hospital affiliated to Nanfang Medical University.
3D printing technology is increasingly used in the medical field. For example, if the patient bone data is input to the computer, the patient bone model can be printed out in advance for the doctor to exercise in advance to ensure more stable and accurate operation. At present, the research led by Wang Liming, a professor at Nanjing Medical University and the chairman of the Jiangsu Digital Medical Association, has achieved 3D printing of bones, blood vessels, tumors, etc., and gradually tried to carry out 3D printed bone "prosthesis" directly filled in The site of the surgical defect.
Yao Qingqiang, Department of Orthopaedics, Nanjing Hospital Affiliated to Southern Medical University, said: "We have been able to apply this technology to "manufacture" the shoulder joint of rabbits, which provides the possibility of cartilage regeneration and repair. At present, this research is leading in the field of orthopedics in China." The researchers will conduct experiments on pigs, step by step close to the human body tissue. "In the future, we may use this technology to complete the repair of tissue defects in the human body."
Yao Qingqiang said that in vitro culture of cartilage requires 3D printing technology to create a "scaffolding"-stent, enriching bone marrow blood in the stent, and using specific methods to induce stem cells to differentiate into chondrocytes. After the culture is completed and inoculated into the body, the stent will slowly degrade by the human body in about 2 years. During the degradation process, the cells can grow in time to fill the space generated by the degradation of the scaffold, and the stability is strong after the growth is completed.
At present, the technology mastered by the Department of Orthopaedics of the Nanjing Hospital affiliated to the Southern Medical University has been able to: remove the stem cells from the body for in vitro culture, and “develop†the cartilage with their own stem cells, which avoids the immune rejection of allogeneic vaccination, carrying viruses, and potential Disadvantages such as the possibility of carcinogenesis. Moreover, the shape of the desired cartilage is printed by 3D printing technology, and after being cultured, the size of the cartilage grown is the same as desired. Yao Qingqiang said: "The combination of 3D printing and tissue engineering will bring about a revolution in individualized implant fabrication and tissue engineering technology, which will greatly promote multidisciplinary advances in organ transplantation, tissue repair and reconstruction, and regenerative medicine."
(Editor)
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